IMPORTANT INFORMATION REGARDING COUNTERFEIT DRUG
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Avastin.com

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Avastin.com

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Other Safety Information

Here are a few things to keep in mind if you're considering treatment with Avastin.

What should I do if I am pregnant or thinking of becoming pregnant?

  • You should not take Avastin while you are pregnant. If you stop Avastin, you should use a contraceptive for at least 6 months after your last dose before attempting to become pregnant

What should I tell my health care provider before taking Avastin?

Avastin therapy may not be appropriate for certain people. Talk to your doctor if you:

  • Are pregnant or think you may be pregnant, or are planning to become pregnant. Based on animal data, Avastin may harm the fetus
  • Are breast-feeding. Avastin may pass into your breast milk
  • Are undergoing surgery. Avastin should not be given for at least 28 days after surgery and until the surgical wound is fully healed
  • Are under the age of 18. The safety and efficacy of Avastin in children have not been evaluated
  • Have recently coughed up blood or have serious bleeding

If you have any questions about Avastin or your health, talk to your doctor or nurse.

Please see full Product Information, including Serious Side Effects, for additional important safety information.

What Does Avastin Treat?

Avastin is approved for:

  • Advanced nonsquamous non–small cell lung cancer (NSCLC) in combination with carboplatin and paclitaxel in people who have not received chemotherapy for their advanced disease

Possible Serious Side Effects

Everyone reacts differently to Avastin therapy. So it’s important to know what the side effects are. Although some people may have a life-threatening side effect, most do not.

Your doctor will stop treatment if any serious side effects occur. Be sure to contact your health care team if you have symptoms related to these side effects.

The most serious side effects (not common, but sometimes fatal):

  • Gastrointestinal (GI) perforation. A hole that develops in your stomach or intestine. Symptoms include pain in the abdomen, nausea, vomiting, constipation, or fever
  • Wounds that don’t heal. A cut made during surgery can be slow to heal or may not fully heal. Avastin should not be used for at least 28 days before or after surgery and until surgical wounds are fully healed
  • Serious bleeding. This includes vomiting or coughing up blood; bleeding in the stomach, brain, or spinal cord; and vaginal bleeding. If you recently coughed up blood or had serious bleeding, do not take Avastin

Other possible serious side effects:

  • Abnormal passage in the body. This forms from one part of the body to another and can sometimes be fatal
  • Stroke or heart problems. These include blood clots, mini-stroke, heart attack, and chest pain. These can sometimes be fatal
  • Severe high blood pressure. Blood pressure that severely spikes or shows signs of affecting the brain. Blood pressure should be monitored every 2 to 3 weeks while on Avastin and after stopping treatment
  • Nervous system and vision problems. Symptoms include high blood pressure, headache, seizure, sluggishness, confusion, and blindness
  • Kidney problems. These may be caused by too much protein in the urine and can sometimes be fatal
  • Infusion reactions. These may include difficulty breathing, chest pain, and excessive sweating. Your doctor or nurse will monitor you for signs of infusion reactions
  • Fertility issues for women. Avastin could cause a woman’s ovaries to stop working and may impair her ability to have children

Additional Safety Information

The most common side effects of Avastin are:

  • Nosebleeds
  • Headache
  • High blood pressure
  • Inflammation of the nose
  • Too much protein in the urine
  • Taste change
  • Dry skin
  • Rectal bleeding
  • Tear production disorder
  • Back pain
  • Inflammation of the skin

Avastin is not right for everyone. Talk to your doctor if you:

  • Are pregnant, may be pregnant, or are breast-feeding. Avastin may harm the fetus or a child that is nursing. If you stop Avastin, you should keep using birth control for at least 6 months after your last dose before trying to become pregnant
  • Are undergoing surgery. Don’t take Avastin for at least 28 days before or after surgery and until surgical wounds are fully healed

If you have any questions about your condition or treatment, talk to your doctor.

Please see full Product Information, including Serious Side Effects, for additional important safety information.