Avastin® (bevacizumab), used with interferon alfa, is approved to treat metastatic kidney cancer.

Possible serious side effects

Everyone reacts differently to Avastin therapy. So, it's important to know what the side effects are. Although some people may have a life-threatening side effect, most do not. Your doctor will stop treatment if any serious side effects occur. Be sure to contact your health care team if there are any signs of these side effects.

Most serious side effects (not common, but sometimes fatal):

  • GI perforation. A hole that develops in your stomach or intestine. Symptoms include pain in your abdomen, nausea, vomiting, constipation, or fever
  • Wounds that don't heal. A cut made during surgery can be slow to heal or may not fully heal. Avastin should not be used for at least 28 days before or after surgery and until surgical wounds are fully healed
  • Serious bleeding. This includes vomiting or coughing up blood; bleeding in the stomach, brain, or spinal cord; nosebleeds; and vaginal bleeding. If you recently coughed up blood or had serious bleeding, be sure to tell your doctor

In studies, when patients took Avastin and interferon alfa instead of interferon alfa alone:

Metastatic renal cell carcinoma benefits

Individual results may vary. Avastin with interferon alfa was not shown to help patients live longer.

What are the side effects of Avastin in mRCC?

See the table below for select side effects that increased by 2% or more in patients who added Avastin to interferon alfa.

Side effects of Avastin RCC

*This included nosebleeds, coughing up blood, bleeding of the gums, bleeding in the small and large intestines, and bleeding in the brain, stomach, respiratory tract and skull.

To learn about the possible side effects of taking Avastin, visit the Side Effects page.

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How Avastin is designed to work


Avastin is a tumor starving therapy. Read more about how it’s designed to work.

Avastin® (bevacizumab) Patient Resources


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