Avastin® (bevacizumab), in combination with carboplatin and paclitaxel, is approved to treat advanced nonsquamous non–small cell lung cancer (nsNSCLC) in people who have not yet received chemotherapy for their advanced disease.

In a clinical study, Avastin was shown to extend the life of people with advanced nsNSCLC when taken with carboplatin and paclitaxel (chemotherapy) instead of chemotherapy alone (12.3 months vs. 10.3 months).

In a clinical study, it was shown that adding Avastin to carboplatin and paclitaxel (chemotherapy) can help people with advanced nsNSCLC:

Advanced non small cell lung cancer benefits

Individual results may vary.

Possible serious side effects

Everyone reacts differently to Avastin therapy. So, it's important to know what the side effects are. Although some people may have a life-threatening side effect, most do not. Your doctor will stop treatment if any serious side effects occur. Be sure to contact your health care team if there are any signs of these side effects.

Most serious side effects (not common, but sometimes fatal):

  • GI perforation. A hole that develops in your stomach or intestine. Symptoms include pain in your abdomen, nausea, vomiting, constipation, or fever
  • Wounds that don't heal. A cut made during surgery can be slow to heal or may not fully heal. Avastin should not be used for at least 28 days before or after surgery and until surgical wounds are fully healed
  • Serious bleeding. This includes vomiting or coughing up blood; bleeding in the stomach, brain, or spinal cord; nosebleeds; and vaginal bleeding. If you recently coughed up blood or had serious bleeding, be sure to tell your doctor

What are the side effects of Avastin in advanced nsNSCLC?

See the table below for select side effects that increased by 2% or more in patients who added Avastin to carboplatin and paclitaxel (chemotherapy).

Life-threatening to fatal side effects

To learn about the possible side effects of taking Avastin, visit the Side Effects page.

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