Everyone reacts differently to Avastin® (bevacizumab) therapy. So, it’s important to know what the side effects are. Although some people may have a life-threatening side effect, most do not. Your doctor will stop treatment if any serious side effects occur. Be sure to contact your health care team if there are any signs of these side effects.
Serious side effects (not common, but sometimes fatal):
A hole that develops in your stomach or intestine. Symptoms include pain in your abdomen, nausea, vomiting, constipation, or fever
A cut made during surgery can be slow to heal or may not fully heal. Avastin should not be used for at least 28 days before or after surgery and until surgical wounds are fully healed
This includes vomiting or coughing up blood; bleeding in the stomach, brain, or spinal cord; nosebleeds; and vaginal bleeding. If you recently coughed up blood or had serious bleeding, be sure to tell your doctor
Blood pressure that severely spikes or shows signs of affecting the brain. Blood pressure should be monitored every 2 to 3 weeks while on Avastin and after stopping treatment
These may include blood clots, mini-stroke, heart attack, chest pain, and your heart may become too weak to pump blood to other parts of your body (congestive heart failure). These can sometimes be fatal
These may be caused by too much protein in the urine and can sometimes be fatal
These were uncommon with the first dose (less than 3% of patients). 0.4% of patients had severe reactions. Infusion-related reactions include high blood pressure or severe high blood pressure that may lead to stroke, trouble breathing, decreased oxygen in red blood cells, a serious allergic reaction, chest pain, headache, tremors, and excessive sweating. Your doctor or nurse will monitor you for signs of infusion-related reactions
This type of passage—known as a fistula—is an irregular connection from one part of the body to another and can sometimes be fatal
Signs include headache, seizure, high blood pressure, sluggishness, confusion, and blindness
In clinical studies across different types of cancer, some patients experienced the following side effects:
Talk to your doctor if you are:
Avastin should not be used for 28 days before or after surgery and until surgical wounds are fully healed
Data have shown that Avastin may harm your unborn baby. Use birth control while on Avastin. If you stop Avastin, you should keep using birth control for 6 months before trying to become pregnant
Taking Avastin could cause a woman’s ovaries to stop working and may impair her ability to have children
Breastfeeding while on Avastin may harm your baby, therefore, women should not breastfeed during and for 6 months after taking Avastin
For more information about your treatment or condition, talk to your doctor.
See the table below for select side effects that increased by 2% or more in patients who added Avastin to carboplatin and paclitaxel (chemotherapy).
See the tables below for select side effects that increased by 2% or more in patients who added Avastin to IV 5–FU–based chemotherapy.
See the table below for select side effects that increased by 2% or more in patients who added Avastin to interferon alfa.
*This included nosebleeds, coughing up blood, bleeding of the gums, bleeding in the small and large intestines, and bleeding in the brain, stomach, respiratory tract and skull.
See the table below for select side effects that increased by 2% or more in patients who added Avastin to carboplatin and paclitaxel (chemotherapy) followed by Avastin alone or who added Avastin to carboplatin and paclitaxel (chemotherapy) followed by placebo compared to chemotherapy alone.
In one study, the most common severe to life-threatening side effects that increased by 2% or more in people who received Avastin plus carboplatin and gemcitabine (chemotherapy) compared to those who received placebo plus chemotherapy or vice versa (refer to the last 2 rows of the table) were:
In a separate study, the most common severe to life-threatening side effects that increased by 2% or more in people who received Avastin plus carboplatin and paclitaxel (chemotherapy) compared to those who received chemotherapy were:
The most common severe to life-threatening side effects that increased by 2% or more in people who received Avastin plus chemotherapy (compared with those receiving chemotherapy alone):
Questions about Avastin treatment costs? Let us help you understand your financial assistance options.
Avastin is a tumor-starving therapy. Read more about how it's designed to work.
Find helpful information and support.
The information contained in this section of the site is intended for U.S. healthcare professionals only. Click "OK" if you are a healthcare professional.
The link you have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc. Genentech, Inc. makes no representation as to the accuracy of the information contained on sites we do not own or control. Genentech does not recommend and does not endorse the content on any third-party websites. Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites.