Avastin® (bevacizumab), in combination with carboplatin and paclitaxel, followed by Avastin alone, is used for the treatment of patients with advanced (Stage III or IV) epithelial ovarian, fallopian tube, or primary peritoneal cancer following initial surgery.

Avastin is used with chemotherapy to treat 2 different types of recurrent ovarian cancer: platinum-sensitive and platinum-resistant.

Avastin, in combination with paclitaxel, pegylated liposomal doxorubicin or topotecan, is approved to treat platinum-resistant recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer (prOC) in women who received no more than two prior chemotherapy treatments.

Avastin, either in combination with carboplatin and paclitaxel or with carboplatin and gemcitabine, followed by Avastin alone, is approved for the treatment of patients with platinum-sensitive recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer (psOC).

What is advanced (stage III or IV) ovarian cancer?

Advanced (stage III or IV) ovarian cancer is generally cancer that has not been treated with chemotherapy or other medicines before. Avastin is given after surgery along with chemotherapy for advanced ovarian cancer.

The benefits of Avastin therapy in advanced (stage III or IV) ovarian cancer

In a clinical study, Avastin, when taken with carboplatin and paclitaxel (chemotherapy) followed by Avastin alone, was shown to extend the length of time people with advanced ovarian cancer lived without their tumors growing or spreading, compared with chemotherapy alone (18.2 months vs 12.0 months).

When patients took Avastin with carboplatin and paclitaxel (chemotherapy) followed by Avastin alone instead of chemotherapy alone:

Individual results may vary.

What is the difference between platinum-sensitive and platinum-resistant cancers?

Recurrent ovarian cancer is cancer that has come back some time after first treatment with platinum-based chemotherapy. Cancer that comes back within 6 months following first treatment is called platinum-resistant, and cancer that comes back more than 6 months after initial treatment is referred to as platinum-sensitive.

Avastin® (bevacizumab) progression timeline

The benefits of Avastin therapy in platinum-sensitive ovarian cancer

In clinical studies, when women with platinum-sensitive ovarian cancer took Avastin with chemotherapy (either in combination with carboplatin and paclitaxel or in combination with carboplatin and gemcitabine) instead of chemotherapy alone:

The benefits of Avastin therapy for platinum-sensitive ovarian cancer infographic

Individual results may vary.

The benefits of Avastin therapy in platinum-resistant ovarian cancer

In clinical studies, when women with platinum-resistant ovarian cancer took Avastin with chemotherapy (paclitaxel, pegylated liposomal doxorubicin, or topotecan) instead of chemotherapy alone:  

The benefits of Avastin therapy for platinum-resistant ovarian cancer infographic

More than 50% of patients who initially responded were still responding at: 9.4 months vs. 5.4 months.

Individual results may vary.

Possible serious side effects

Everyone reacts differently to Avastin therapy. So, it's important to know what the side effects are. Although some people may have a life-threatening side effect, most do not. Your doctor will stop treatment if any serious side effects occur. Be sure to contact your health care team if there are any signs of these side effects.

Most serious side effects (not common, but sometimes fatal):

  • GI perforation. A hole that develops in your stomach or intestine. Symptoms include pain in your abdomen, nausea, vomiting, constipation, or fever
  • Wounds that don't heal. A cut made during surgery can be slow to heal or may not fully heal. Avastin should not be used for at least 28 days before or after surgery and until surgical wounds are fully healed
  • Serious bleeding. This includes vomiting or coughing up blood; bleeding in the stomach, brain, or spinal cord; nosebleeds; and vaginal bleeding. If you recently coughed up blood or had serious bleeding, be sure to tell your doctor

What are the side effects of Avastin in advanced (stage III or IV) ovarian cancer?

See the table below for common severe to life-threatening (grade 3 or 4) side effects that increased by 2% or more in patients who added Avastin to carboplatin and paclitaxel (chemotherapy) followed by Avastin alone or who added Avastin to carboplatin and paclitaxel (chemotherapy) followed by placebo compared to chemotherapy alone.

What are the side effects of Avastin in psOC?

In one study, the most common severe to life-threatening side effects that increased by 2% or more in people who received Avastin plus carboplatin and gemcitabine (chemotherapy) compared to those who received placebo plus chemotherapy or vice versa (refer to the last 2 rows of the table) were:

What are the side effects of Avastin in psOC?

In a separate study, the most common severe to life-threatening side effects that increased by 2% or more in people who received Avastin plus carboplatin and paclitaxel (chemotherapy) compared to those who received chemotherapy were:

What are the side effects of Avastin in prOC?

The most common severe to life-threatening side effects that increased by 2% or more in people who received Avastin plus chemotherapy (compared with those receiving chemotherapy alone) were:

Financial resources calculator

GET FINANCIAL SUPPORT

Questions about Avastin treatment costs? Let us help you understand your financial assistance options.

How Avastin is designed to work

FIND OUT HOW AVASTIN IS DESIGNED TO WORK

Avastin is a tumor starving therapy. Read more about how it’s designed to work.

Avastin® (bevacizumab) Patient Resources

PATIENT RESOURCES

Find helpful information and support.